Myeloproliferative neoplasm related nephropathy

Case Report

Author Details : Biji K Aravind*, Dhanya P G, Jojo Pullockara, Deepak Charles

Volume : 6, Issue : 4, Year : 2021

Article Page : 331-333

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Primary Myelofibrosis associated Nephropathy is a recently described entity. Primary Myelofibrosis (PMF) is a Myeloproliferative Neoplasm (MPN) where the marrow space shows fibrosis with megakaryocyte dysplasia. We present a case of a 32 year old patient who was detected to have proteinuria, renal dysfunction and anemia ,on a routine health check up. Primary Myelofibrosis was confirmed by positive Jak 2 expression. Kidney biopsy showed focal segmental glomerulosclerosis along with thickened glomerular basement membrane. The histomorphological features of renal and bonemarrow biopsies are analysed and a detailed review of the literature is done.

Keywords: Myeloproliferative neoplasm, Focal segmental glomeruloscerosis, Primary myelofibrosis

How to cite : Aravind B K, Dhanya P G, Pullockara J, Charles D, Myeloproliferative neoplasm related nephropathy. IP J Diagn Pathol Oncol 2021;6(4):331-333

Copyright © 2021 by author(s) and IP J Diagn Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

Article History

Received : 10-05-2021

Accepted : 12-05-2021

Available online : 26-11-2021

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