Undifferentiated carcinoma with osteoclastic giant cells of pancreas: Case report and brief literature review


Case Report

Author Details : Jyoti Parag Dekate*, Manjula V Kelkeri, Gowri Garudadri

Volume : 6, Issue : 4, Year : 2021

Article Page : 307-310

https://doi.org/10.18231/j.jdpo.2021.065



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Abstract

Undifferentiated carcinoma with osteoclastic giant cells is a distinctive rare neoplasm involving pancreas and rarely bile ducts. This neoplasm shows characteristic histologic features with variable admixture of mononuclear histiocytic cells, non- neoplastic osteoclastic giant cells and neoplastic mononuclear cell component. Though, this tumor has been shown to share genetic alterations with pancreatic ductal adenocarcinoma, clinically, it behaves unpredictably with a substantial proportion of patient showing prolonged survival period. We present a case of this rare pancreatic tumour with brief literature review discussing the key pathologic features, immunophenotype, genetic profile and clinical behavior.
Key Message: Undifferentiated carcinoma with osteoclastic giant cells is a rare neoplasm in pancreas which is believed to be of epithelial origin and shares genetic aberrations with ductal adenocarcinoma. Despite this, these tumours have better prognosis with prolonged survival period.
 
Keywords: Undifferentiated carcinoma, Osteoclastic giant cells


How to cite : Dekate J P, Kelkeri M V, Garudadri G, Undifferentiated carcinoma with osteoclastic giant cells of pancreas: Case report and brief literature review. IP J Diagn Pathol Oncol 2021;6(4):307-310


Copyright © 2021 by author(s) and IP J Diagn Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)





Article History

Received : 24-08-2021

Accepted : 21-10-2021

Available online : 26-11-2021


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Article DOI

https://doi.org/10.18231/j.jdpo.2021.065


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