Occult multifocal papillary thyroid carcinoma presenting as anaplastic carcinoma in the metastatic neck deposit – A rare case report along with review of literature


Case Report

Author Details : Yasmin A. Momin, Jaydeep N. Pol, Alka V. Gosavi, Arti R. Anvikar*

Volume : 6, Issue : 3, Year : 2021

Article Page : 216-222

https://doi.org/10.18231/j.jdpo.2021.046



Suggest article by email

Abstract

Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma that carries a favourable prognosis. However, a small subset unfortunately shows transformation to least differentiated anaplastic carcinoma (AC) having a highly aggressive behavior. This process usually occurs within thyroid but is rare in metastatic cervical lymph node or soft tissue neck and exceedingly rare at distant sites. We report a unique case of a 75 years female who presented with anaplastic carcinoma in metastatic neck deposit with occult papillary thyroid carcinoma. To the best of our knowledge, this is the first case in the world literature having anaplastic transformation (AT) in the metastatic neck deposit, right at the presentation with a totally unnoticed PTC clinically. We present this case to emphasize that the transformation process can occur even when the differentiated malignancy in thyroid is small, insignificant or hidden and that metastasis solely can be the presenting feature which can be misleading clinically and even histopathologically. As AC is very aggressive, there is need for early and precise diagnosis & prompt therapeutic intervention.


Keywords: Anaplastic carcinoma, Transformation, Papillary thyroid carcinoma, Dedifferentiation, Immunohistochemistry


How to cite : Momin Y A, Pol J N, Gosavi A V, Anvikar A R, Occult multifocal papillary thyroid carcinoma presenting as anaplastic carcinoma in the metastatic neck deposit – A rare case report along with review of literature. IP J Diagn Pathol Oncol 2021;6(3):216-222


Copyright © 2021 by author(s) and IP J Diagn Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)



Article History

Received : 14-08-2021

Accepted : 26-08-2021

Available online : 14-09-2021


View Article

PDF File   Full Text Article


Downlaod

PDF File   XML File   ePub File


Digital Object Identifier (DOI)

Article DOI

https://doi.org/10.18231/j.jdpo.2021.046


Article Metrics






Article Access statistics

Viewed: 46

PDF Downloaded: 26



Wiki in hindi